[177Lu]Lu-DOTA-ZOL bone pain palliation in patients with skeletal metastases from various cancers: efficacy and safety results
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چکیده
منابع مشابه
Lu-edtmp: a New Radiopharmaceutical for Palliation of Bone Pain in Cancer Patients with Skeletal Metastases
Skeletal metastases or secondary cancerous lesions in bone, are common in patients suffering from breast, lung and prostate cancer, in the advanced stage of the disease. These metastatic lesions in skeleton, often lead to excruciating pain and other related symptoms such as: lack of mobility, neurological deficits, depression, anxiety, anger, fear of death etc., which adversely affect the quali...
متن کاملComparative Therapeutic Efficacy of 153Sm-EDTMP and 177Lu-EDTMP for Bone Pain Palliation in Patients with Skeletal Metastases: Patients’ Pain Score Analysis and Personalized Dosimetry
INTRODUCTION The aim of the present study was to compare the therapeutic efficacy of 153Sm-EDTMP and 177Lu-EDTMP in pain palliation in cancer patients with skeletal metastases. MATERIALS AND METHODS Thirty patients (25 M:5 F, mean age: 66.0 ± 14.7 years) of breast/prostate cancer with documented skeletal metastases were recruited prospectively. Twenty patients were considered randomly for tre...
متن کاملRadiopharmaceutical therapy for palliation of bone pain from osseous metastases.
Bone metastasis occurs as a result of a complex pathophysiologic process between host and tumor cells leading to cellular invasion, migration adhesion, and stimulation of osteoclastic and osteoblastic activity. The process is mediated by parathyroid hormones, cytokines, and tumor-derived factors. Several sequelae occur as a result of osseous metastases and resulting bone pain can lead to signif...
متن کاملSamarium-153 ethylenediamine tetramethylene phosphonate therapy for bone pain palliation in skeletal metastases.
BACKGROUND Systemic therapy with radionuclides may be used for the treatment of patients with painful skeletal metastases owing to its efficacy, low cost and low toxicity. Imported radionuclides for pain palliation, like Strontium-89 are expensive; particularly for developing countries. In the Indian scenario, Samarium-153 (Sm-153) is produced in our own reactors and as a result, it is readily ...
متن کاملPain Palliation in Patients with Bone Metastases Using Magnetic Resonance-Guided Focused Ultrasound with Conformal Bone System: A Preliminary Report
PURPOSE We evaluated the safety and effectiveness of the Magnetic Resonance-guided Focused Ultrasound (MRgFUS) with the ExAblate Conformal Bone System for the palliation of painful bone metastases. MATERIALS AND METHODS Our Institutional Review Board approved this study, and all patients gave informed consent prior to enrollment. A total of six painful metastatic bone lesions in five patients...
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ژورنال
عنوان ژورنال: EJNMMI Research
سال: 2020
ISSN: 2191-219X
DOI: 10.1186/s13550-020-00709-y